| 1. Ronde | 14.08.2021 | FC Augsburg [A-jun] | - | Kickers Offenbach [A-jun] | 3:1 | ||||
| 2. Ronde | 21.08.2021 | Kickers Offenbach [A-jun] | - | 1. FC Saarbrücken [A-jun] | 3:1 | ||||
| 3. Ronde | 11.09.2021 | VfB Stuttgart [A-jun] | - | Kickers Offenbach [A-jun] | 3:0 |  |
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| 4. Ronde | 18.09.2021 | Kickers Offenbach [A-jun] | - | Eintracht Frankfurt [A-jun] | 0:3 | ||||
| 5. Ronde | 25.09.2021 | 1899 Hoffenheim [A-jun] | - | Kickers Offenbach [A-jun] | 6:1 | |
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| 6. Ronde | 02.10.2021 | Kickers Offenbach [A-jun] | - | Hessen Kassel [A-jun] | 3:0 | ||||
| 7. Ronde | 16.10.2021 | 1. FC Nürnberg [A-jun] | - | Kickers Offenbach [A-jun] | 3:0 | ||||
| 8. Ronde | 23.10.2021 | Kickers Offenbach [A-jun] | - | SpVgg Greuther Fürth [A-jun] | 2:3 | |
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| 20. Ronde | 23.04.2022 | SSV Ulm 1846 [A-jun] | - | Kickers Offenbach [A-jun] | 2:1 | ||||
| 21. Ronde | 30.04.2022 | Kickers Offenbach [A-jun] | - | Bayern München [A-jun] | 3:2 |
Duitsland