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| 30.10.2021 | 11:00 | SpVgg Greuther Fürth | - | SC Freiburg | 0:1 (0:1) | |
| 11:00 | Hessen Kassel | - | Bayern München | 0:7 (0:1) | ||
| 13:00 | Eintracht Frankfurt | - | 1. FC Saarbrücken | 3:0 (1:0) | ||
| 14:00 | 1. FC Nürnberg | - | SSV Ulm 1846 | 2:1 (2:0) | ||
| 14:00 | Karlsruher SC | - | 1. FC Heidenheim 1846 | 2:2 (2:0) | ||
| 31.10.2021 | 11:00 | 1899 Hoffenheim | - | FC Augsburg | 2:4 (0:3) | |
| 11:00 | SpVgg Unterhaching | - | 1. FC Kaiserslautern | 3:0 (0:0) | ||
| 11:00 | FC-Astoria Walldorf | - | SV Darmstadt 98 | 1:1 (1:0) | ||
| 13:00 | FC Ingolstadt 04 | - | Stuttgarter Kickers | 4:1 (3:0) | ||
| 13:00 | 1. FSV Mainz 05 | - | Kickers Offenbach | 4:0 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Nürnberg | 9 | 8 | 0 | 1 | 24:10 | 14 | 24 |
| 2 |
|
VfB Stuttgart | 8 | 6 | 1 | 1 | 22:7 | 15 | 19 |
| 3 |
|
1899 Hoffenheim | 9 | 5 | 2 | 2 | 35:20 | 15 | 17 |
| 4 |
|
Eintracht Frankfurt | 9 | 5 | 2 | 2 | 27:12 | 15 | 17 |
| 5 |
|
SpVgg Unterhaching | 8 | 5 | 2 | 1 | 15:8 | 7 | 17 |
| 6 |
|
FC Augsburg | 8 | 5 | 2 | 1 | 17:11 | 6 | 17 |
| 7 |
|
1. FSV Mainz 05 | 9 | 5 | 1 | 3 | 28:12 | 16 | 16 |
| 8 |
|
1. FC Heidenheim 1846 | 9 | 4 | 2 | 3 | 17:13 | 4 | 14 |
| 9 |
|
Bayern München | 8 | 4 | 1 | 3 | 22:12 | 10 | 13 |
| 10 |
|
SC Freiburg | 9 | 4 | 1 | 4 | 19:21 | -2 | 13 |
| 11 |
|
SV Darmstadt 98 | 9 | 3 | 3 | 3 | 9:16 | -7 | 12 |
| 12 |
|
Karlsruher SC | 8 | 2 | 5 | 1 | 12:10 | 2 | 11 |
| 13 |
|
FC Ingolstadt 04 | 8 | 3 | 1 | 4 | 16:15 | 1 | 10 |
| 14 |
|
SSV Ulm 1846 | 8 | 3 | 0 | 5 | 12:14 | -2 | 9 |
| 15 |
|
SpVgg Greuther Fürth | 9 | 2 | 3 | 4 | 9:14 | -5 | 9 |
| 16 |
|
1. FC Kaiserslautern | 9 | 3 | 0 | 6 | 17:30 | -13 | 9 |
| 17 |
|
Stuttgarter Kickers | 9 | 2 | 2 | 5 | 12:25 | -13 | 8 |
| 18 |
|
FC-Astoria Walldorf | 8 | 1 | 4 | 3 | 11:18 | -7 | 7 |
| 19 |
|
Kickers Offenbach | 9 | 2 | 0 | 7 | 10:26 | -16 | 6 |
| 20 |
|
1. FC Saarbrücken | 8 | 1 | 0 | 7 | 5:19 | -14 | 3 |
| 21 |
|
Hessen Kassel | 9 | 1 | 0 | 8 | 4:30 | -26 | 3 |
| Play-offs | |
| Degradatie |
