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| 18.04.2021 | 14:00 | CA Osasuna | - | Elche CF | 2:0 (1:0) | |
| 14:00 | Real Sociedad | - | Sevilla FC | 1:2 (1:2) | ||
| 16:15 | Deportivo Alavés | - | SD Huesca | 1:0 (0:0) | ||
| 16:15 | Atlético Madrid | - | SD Eibar | 5:0 (2:0) | ||
| 18:30 | Real Betis | - | Valencia CF | 2:2 (2:1) | ||
| 18:30 | Cádiz CF | - | Celta de Vigo | 0:0 (0:0) | ||
| 21:00 | Getafe CF | - | Real Madrid | 0:0 (0:0) | ||
| 21:00 | Levante UD | - | Villarreal CF | 1:5 (1:2) | ||
| 28.04.2021 | 19:00 | Athletic Bilbao | - | Real Valladolid | 2:2 (1:0) | |
| 29.04.2021 | 19:00 | FC Barcelona | - | Granada CF | 1:2 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Madrid | 33 | 22 | 7 | 4 | 60:22 | 38 | 73 |
| 2 |
|
FC Barcelona | 33 | 22 | 5 | 6 | 77:31 | 46 | 71 |
| 3 |
|
Real Madrid | 33 | 21 | 8 | 4 | 56:24 | 32 | 71 |
| 4 |
|
Sevilla FC | 33 | 22 | 4 | 7 | 49:26 | 23 | 70 |
| 5 |
|
Real Sociedad | 33 | 14 | 11 | 8 | 51:34 | 17 | 53 |
| 6 |
|
Real Betis | 33 | 14 | 8 | 11 | 42:45 | -3 | 50 |
| 7 |
|
Villarreal CF | 33 | 12 | 13 | 8 | 50:38 | 12 | 49 |
| 8 |
|
Granada CF | 33 | 13 | 6 | 14 | 43:54 | -11 | 45 |
| 9 |
|
Athletic Bilbao | 33 | 10 | 12 | 11 | 43:36 | 7 | 42 |
| 10 |
|
Celta de Vigo | 33 | 10 | 11 | 12 | 44:51 | -7 | 41 |
| 11 |
|
CA Osasuna | 33 | 10 | 10 | 13 | 31:39 | -8 | 40 |
| 12 |
|
Levante UD | 33 | 9 | 11 | 13 | 38:46 | -8 | 38 |
| 13 |
|
Cádiz CF | 33 | 9 | 10 | 14 | 28:49 | -21 | 37 |
| 14 |
|
Valencia CF | 33 | 8 | 12 | 13 | 41:48 | -7 | 36 |
| 15 |
|
Getafe CF | 33 | 8 | 10 | 15 | 26:39 | -13 | 34 |
| 16 |
|
Deportivo Alavés | 33 | 7 | 10 | 16 | 28:49 | -21 | 31 |
| 17 |
|
Real Valladolid | 33 | 5 | 15 | 13 | 31:45 | -14 | 30 |
| 18 |
|
Elche CF | 33 | 6 | 12 | 15 | 29:49 | -20 | 30 |
| 19 |
|
SD Huesca | 33 | 5 | 12 | 16 | 31:50 | -19 | 27 |
| 20 |
|
SD Eibar | 33 | 4 | 11 | 18 | 23:46 | -23 | 23 |
| Champions League | |
| Europa League | |
| Europa League Kwali. | |
| Degradatie |
