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| 16.04.2022 | 11:00 | Bayern München II | - | FSV Gütersloh 2009 | 2:0 (1:0) | |
| 16:00 | 1899 Hoffenheim II | - | Eintracht Frankfurt II | 1:1 (0:0) | ||
| 17.04.2022 | 11:00 | SV Henstedt-Ulzburg | - | SV 07 Elversberg | 0:0 (0:0) | |
| 11:00 | RB Leipzig | - | Borussia Bocholt | 3:2 (1:2) | ||
| 14:00 | VfL Wolfsburg II | - | SV Meppen | 0:0 (0:0) | ||
| 14:00 | 1. FC Nürnberg | - | FC Ingolstadt 04 | 1:5 (1:2) | ||
| 14:00 | MSV Duisburg | - | SG 99 Andernach | 3:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 20 | 14 | 3 | 3 | 51:16 | 35 | 45 |
| 2 |
|
MSV Duisburg | 20 | 13 | 3 | 4 | 39:22 | 17 | 42 |
| 3 |
|
RB Leipzig | 20 | 12 | 2 | 6 | 51:34 | 17 | 38 |
| 4 |
|
1. FC Nürnberg | 20 | 12 | 1 | 7 | 37:27 | 10 | 37 |
| 5 |
|
SG 99 Andernach | 20 | 10 | 4 | 6 | 42:27 | 15 | 34 |
| 6 |
|
Bayern München II | 20 | 10 | 3 | 7 | 32:33 | -1 | 33 |
| 7 |
|
Eintracht Frankfurt II | 20 | 8 | 6 | 6 | 37:30 | 7 | 30 |
| 8 |
|
FSV Gütersloh 2009 | 20 | 8 | 4 | 8 | 35:30 | 5 | 28 |
| 9 |
|
1899 Hoffenheim II | 20 | 6 | 7 | 7 | 23:28 | -5 | 25 |
| 10 |
|
FC Ingolstadt 04 | 20 | 7 | 2 | 11 | 43:41 | 2 | 23 |
| 11 |
|
SV 07 Elversberg | 20 | 5 | 4 | 11 | 19:40 | -21 | 19 |
| 12 |
|
VfL Wolfsburg II | 20 | 4 | 5 | 11 | 15:32 | -17 | 17 |
| 13 |
|
SV Henstedt-Ulzburg | 20 | 4 | 2 | 14 | 27:60 | -33 | 14 |
| 14 |
|
Borussia Bocholt | 20 | 3 | 2 | 15 | 21:52 | -31 | 11 |
| Promotie | |
| Degradatie |
