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| 26.09.2021 | 15:00 | Germania Ratingen 04/19 | - | Cronenberger SC | 8:2 (3:0) | |
| 15:00 | Schwarz-Weiß Essen | - | 1. FC Kleve | 0:1 (0:0) | ||
| 15:00 | TVD Velbert | - | 1. FC Bocholt | 3:3 (1:0) | ||
| 15:00 | 1. FC Monheim | - | SpVg Schonnebeck | 1:1 (0:1) | ||
| 15:15 | SpVgg Sterkrade-Nord | - | TSV Meerbusch | 2:4 (0:1) | ||
| 15:30 | DJK Teutonia St. Tönis | - | SC Düsseldorf-West | 2:3 (1:2) | ||
| 15:30 | TuRU Düsseldorf | - | SC Union Nettetal | 2:0 (0:0) | ||
| 15:30 | FSV Duisburg | - | Sportfreunde Niederwenigern | 3:3 (3:2) | ||
| 15:30 | VfB 03 Hilden | - | SC Velbert | 3:3 (0:2) | ||
| 15:30 | 1. FC Mönchengladbach | - | TV Jahn Hiesfeld | 0:8 (0:3) | ||
| 10.11.2021 | 19:00 | FC Kray | - | Sportfreunde Baumberg | 0:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Germania Ratingen 04/19 | 6 | 4 | 1 | 1 | 16:4 | 12 | 13 |
| 2 |
|
TVD Velbert | 6 | 4 | 1 | 1 | 10:7 | 3 | 13 |
| 3 |
|
SpVg Schonnebeck | 6 | 3 | 2 | 1 | 17:8 | 9 | 11 |
| 4 |
|
SC Velbert | 6 | 3 | 2 | 1 | 14:7 | 7 | 11 |
| 5 |
|
SSVg Velbert | 5 | 3 | 2 | 0 | 12:5 | 7 | 11 |
| 6 |
|
1. FC Kleve | 6 | 3 | 2 | 1 | 7:5 | 2 | 11 |
| 7 |
|
TuRU Düsseldorf | 6 | 3 | 2 | 1 | 13:10 | 3 | 11 |
| 8 |
|
VfB 03 Hilden | 5 | 3 | 1 | 1 | 10:7 | 3 | 10 |
| 9 |
|
1. FC Bocholt | 5 | 2 | 3 | 0 | 16:7 | 9 | 9 |
| 10 |
|
Sportfreunde Baumberg | 6 | 3 | 0 | 3 | 13:11 | 2 | 9 |
| 11 |
|
Sportfreunde Niederwenigern | 6 | 2 | 3 | 1 | 12:13 | -1 | 9 |
| 12 |
|
Schwarz-Weiß Essen | 6 | 3 | 0 | 3 | 10:12 | -2 | 9 |
| 13 |
|
DJK Teutonia St. Tönis | 6 | 2 | 2 | 2 | 11:11 | 0 | 8 |
| 14 |
|
1. FC Monheim | 6 | 2 | 2 | 2 | 6:6 | 0 | 8 |
| 15 |
|
FC Kray | 6 | 2 | 1 | 3 | 11:14 | -3 | 7 |
| 16 |
|
SC Düsseldorf-West | 6 | 2 | 1 | 3 | 9:14 | -5 | 7 |
| 17 |
|
TSV Meerbusch | 5 | 2 | 0 | 3 | 9:14 | -5 | 6 |
| 18 |
|
Cronenberger SC | 6 | 1 | 2 | 3 | 7:15 | -8 | 5 |
| 19 |
|
TV Jahn Hiesfeld | 6 | 1 | 1 | 4 | 11:12 | -1 | 4 |
| 20 |
|
FSV Duisburg | 5 | 1 | 1 | 3 | 8:10 | -2 | 4 |
| 21 |
|
SC Union Nettetal | 6 | 1 | 0 | 5 | 6:12 | -6 | 3 |
| 22 |
|
1. FC Mönchengladbach | 5 | 1 | 0 | 4 | 6:20 | -14 | 3 |
| 23 |
|
SpVgg Sterkrade-Nord | 6 | 0 | 1 | 5 | 7:17 | -10 | 1 |
| Play-offs | |
| Play-offs |
