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| 01.10.2021 | 19:30 | SSVg Velbert | - | TVD Velbert | 2:1 (1:1) | |
| 19:30 | SC Union Nettetal | - | Germania Ratingen 04/19 | 4:2 (2:2) | ||
| 03.10.2021 | 15:00 | Sportfreunde Baumberg | - | DJK Teutonia St. Tönis | 4:1 (2:1) | |
| 15:00 | SpVg Schonnebeck | - | 1. FC Mönchengladbach | 2:2 (2:1) | ||
| 15:00 | Cronenberger SC | - | 1. FC Monheim | 0:6 (0:3) | ||
| 15:00 | Sportfreunde Niederwenigern | - | VfB 03 Hilden | 0:5 (0:3) | ||
| 15:00 | TV Jahn Hiesfeld | - | FSV Duisburg | 0:0 (0:0) | ||
| 15:00 | 1. FC Kleve | - | FC Kray | 4:4 (2:2) | ||
| 15:00 | TSV Meerbusch | - | Schwarz-Weiß Essen | 0:1 (0:0) | ||
| 15:30 | 1. FC Bocholt | - | SpVgg Sterkrade-Nord | 8:0 (3:0) | ||
| 15:30 | SC Düsseldorf-West | - | TuRU Düsseldorf | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 6 | 4 | 2 | 0 | 14:6 | 8 | 14 |
| 2 |
|
TuRU Düsseldorf | 7 | 4 | 2 | 1 | 14:10 | 4 | 14 |
| 3 |
|
Germania Ratingen 04/19 | 7 | 4 | 1 | 2 | 18:8 | 10 | 13 |
| 4 |
|
VfB 03 Hilden | 6 | 4 | 1 | 1 | 15:7 | 8 | 13 |
| 5 |
|
TVD Velbert | 7 | 4 | 1 | 2 | 11:9 | 2 | 13 |
| 6 |
|
1. FC Bocholt | 6 | 3 | 3 | 0 | 24:7 | 17 | 12 |
| 7 |
|
SpVg Schonnebeck | 7 | 3 | 3 | 1 | 19:10 | 9 | 12 |
| 8 |
|
Sportfreunde Baumberg | 7 | 4 | 0 | 3 | 17:12 | 5 | 12 |
| 9 |
|
1. FC Kleve | 7 | 3 | 3 | 1 | 11:9 | 2 | 12 |
| 10 |
|
Schwarz-Weiß Essen | 7 | 4 | 0 | 3 | 11:12 | -1 | 12 |
| 11 |
|
SC Velbert | 6 | 3 | 2 | 1 | 14:7 | 7 | 11 |
| 12 |
|
1. FC Monheim | 7 | 3 | 2 | 2 | 12:6 | 6 | 11 |
| 13 |
|
Sportfreunde Niederwenigern | 7 | 2 | 3 | 2 | 12:18 | -6 | 9 |
| 14 |
|
FC Kray | 7 | 2 | 2 | 3 | 15:18 | -3 | 8 |
| 15 |
|
DJK Teutonia St. Tönis | 7 | 2 | 2 | 3 | 12:15 | -3 | 8 |
| 16 |
|
SC Düsseldorf-West | 7 | 2 | 1 | 4 | 9:15 | -6 | 7 |
| 17 |
|
SC Union Nettetal | 7 | 2 | 0 | 5 | 10:14 | -4 | 6 |
| 18 |
|
TSV Meerbusch | 6 | 2 | 0 | 4 | 9:15 | -6 | 6 |
| 19 |
|
TV Jahn Hiesfeld | 7 | 1 | 2 | 4 | 11:12 | -1 | 5 |
| 20 |
|
FSV Duisburg | 6 | 1 | 2 | 3 | 8:10 | -2 | 5 |
| 21 |
|
Cronenberger SC | 7 | 1 | 2 | 4 | 7:21 | -14 | 5 |
| 22 |
|
1. FC Mönchengladbach | 6 | 1 | 1 | 4 | 8:22 | -14 | 4 |
| 23 |
|
SpVgg Sterkrade-Nord | 7 | 0 | 1 | 6 | 7:25 | -18 | 1 |
| Play-offs | |
| Play-offs |
