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| 15.10.2022 | 14:00 | 1. FC Köln II | - | 1. FC Bocholt | 1:3 (0:1) | |
| 14:00 | SV 19 Straelen | - | Alemannia Aachen | 2:4 (1:0) | ||
| 14:00 | Bor. Mönchengladbach II | - | Fortuna Köln | 1:2 (0:1) | ||
| 14:00 | 1. FC Düren | - | Fortuna Düsseldorf II | 0:2 (0:1) | ||
| 14:00 | FC Schalke 04 II | - | Rot Weiss Ahlen | 2:2 (0:0) | ||
| 14:00 | SV Rödinghausen | - | SG Wattenscheid 09 | 3:0 (2:0) | ||
| 14:00 | SV Lippstadt 08 | - | SC Wiedenbrück | 3:3 (0:1) | ||
| 16.10.2022 | 14:00 | Rot-Weiß Oberhausen | - | Preußen Münster | 3:2 (1:1) | |
| 14:00 | 1. FC Kaan-Marienborn | - | Wuppertaler SV | 1:2 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Preußen Münster | 12 | 8 | 2 | 2 | 29:13 | 16 | 26 |
| 2 |
|
SV Rödinghausen | 12 | 8 | 1 | 3 | 27:9 | 18 | 25 |
| 3 |
|
Rot-Weiß Oberhausen | 12 | 6 | 3 | 3 | 25:23 | 2 | 21 |
| 4 |
|
Fortuna Köln | 12 | 6 | 3 | 3 | 14:12 | 2 | 21 |
| 5 |
|
FC Schalke 04 II | 12 | 6 | 2 | 4 | 24:18 | 6 | 20 |
| 6 |
|
SV Lippstadt 08 | 12 | 6 | 1 | 5 | 21:23 | -2 | 19 |
| 7 |
|
Alemannia Aachen | 12 | 5 | 3 | 4 | 19:18 | 1 | 18 |
| 8 |
|
1. FC Kaan-Marienborn | 12 | 5 | 3 | 4 | 17:19 | -2 | 18 |
| 9 |
|
Bor. Mönchengladbach II | 12 | 4 | 5 | 3 | 20:16 | 4 | 17 |
| 10 |
|
Wuppertaler SV | 12 | 4 | 4 | 4 | 21:18 | 3 | 16 |
| 11 |
|
Fortuna Düsseldorf II | 12 | 5 | 1 | 6 | 18:22 | -4 | 16 |
| 12 |
|
1. FC Köln II | 12 | 5 | 1 | 6 | 22:27 | -5 | 16 |
| 13 |
|
1. FC Düren | 12 | 5 | 1 | 6 | 16:23 | -7 | 16 |
| 14 |
|
SC Wiedenbrück | 12 | 4 | 3 | 5 | 19:15 | 4 | 15 |
| 15 |
|
1. FC Bocholt | 12 | 4 | 3 | 5 | 22:23 | -1 | 15 |
| 16 |
|
Rot Weiss Ahlen | 12 | 3 | 4 | 5 | 21:21 | 0 | 13 |
| 17 |
|
SV 19 Straelen | 12 | 2 | 0 | 10 | 9:21 | -12 | 6 |
| 18 |
|
SG Wattenscheid 09 | 12 | 1 | 2 | 9 | 12:35 | -23 | 5 |
| Promotie | |
| Degradatie | |
| Degradatie |
