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| 10.04.1981 | 20:00 | Borussia Dortmund | - | VfL Bochum | 1:3 (0:2) | |
| 11.04.1981 | 15:30 | Fortuna Düsseldorf | - | TSV 1860 München | 2:1 (1:1) | |
| 15:30 | FC Schalke 04 | - | Hamburger SV | 2:1 (1:0) | ||
| 15:30 | Arminia Bielefeld | - | VfB Stuttgart | 1:0 (0:0) | ||
| 15:30 | Eintracht Frankfurt | - | 1. FC Köln | 4:0 (2:0) | ||
| 15:30 | Bor. Mönchengladbach | - | 1. FC Kaiserslautern | 1:0 (0:0) | ||
| 15:30 | Bayer 05 Uerdingen | - | 1. FC Nürnberg | 3:2 (2:1) | ||
| 15:30 | Bayern München | - | MSV Duisburg | 5:1 (2:1) | ||
| 15:30 | SV Bayer 04 Leverkusen | - | Karlsruher SC | 3:0 (2:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 28 | 16 | 9 | 3 | 67:38 | 29 | 41:15 |
| 2 |
|
Hamburger SV | 28 | 18 | 5 | 5 | 63:36 | 27 | 41:15 |
| 3 |
|
1. FC Kaiserslautern | 28 | 13 | 9 | 6 | 50:31 | 19 | 35:21 |
| 4 |
|
VfB Stuttgart | 28 | 14 | 7 | 7 | 55:38 | 17 | 35:21 |
| 5 |
|
Eintracht Frankfurt | 28 | 13 | 8 | 7 | 52:39 | 13 | 34:22 |
| 6 |
|
Borussia Dortmund | 28 | 11 | 7 | 10 | 60:51 | 9 | 29:27 |
| 7 |
|
1. FC Köln | 28 | 10 | 9 | 9 | 46:44 | 2 | 29:27 |
| 8 |
|
VfL Bochum | 28 | 7 | 14 | 7 | 43:37 | 6 | 28:28 |
| 9 |
|
Bor. Mönchengladbach | 28 | 11 | 6 | 11 | 48:52 | -4 | 28:28 |
| 10 |
|
Karlsruher SC | 28 | 7 | 12 | 9 | 39:50 | -11 | 26:30 |
| 11 |
|
SV Bayer 04 Leverkusen | 28 | 8 | 9 | 11 | 43:45 | -2 | 25:31 |
| 12 |
|
Fortuna Düsseldorf | 28 | 9 | 7 | 12 | 51:54 | -3 | 25:31 |
| 13 |
|
MSV Duisburg | 28 | 7 | 9 | 12 | 34:48 | -14 | 23:33 |
| 14 |
|
1. FC Nürnberg | 28 | 9 | 4 | 15 | 41:52 | -11 | 22:34 |
| 15 |
|
FC Schalke 04 | 28 | 8 | 6 | 14 | 39:69 | -30 | 22:34 |
| 16 |
|
Bayer 05 Uerdingen | 28 | 8 | 5 | 15 | 42:58 | -16 | 21:35 |
| 17 |
|
TSV 1860 München | 28 | 7 | 6 | 15 | 40:54 | -14 | 20:36 |
| 18 |
|
Arminia Bielefeld | 28 | 7 | 6 | 15 | 38:55 | -17 | 20:36 |
