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| 15.04.2006 | 15:30 | MSV Duisburg | - | Hamburger SV | 0:2 (0:2) | |
| 15:30 | FC Schalke 04 | - | 1. FC Köln | 1:1 (0:1) | ||
| 15:30 | Bayer Leverkusen | - | Bor. Mönchengladbach | 2:1 (1:0) | ||
| 15:30 | Hertha BSC | - | Borussia Dortmund | 0:0 (0:0) | ||
| 15:30 | Eintracht Frankfurt | - | 1. FSV Mainz 05 | 0:0 (0:0) | ||
| 15:30 | Bayern München | - | Arminia Bielefeld | 2:0 (0:0) | ||
| 15:30 | VfL Wolfsburg | - | Werder Bremen | 1:1 (1:1) | ||
| 16.04.2006 | 17:30 | 1. FC Nürnberg | - | 1. FC Kaiserslautern | 3:2 (1:1) | |
| 17:30 | Hannover 96 | - | VfB Stuttgart | 3:3 (2:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 30 | 21 | 6 | 3 | 58:25 | 33 | 69 |
| 2 |
|
Hamburger SV | 30 | 20 | 5 | 5 | 49:22 | 27 | 65 |
| 3 |
|
Werder Bremen | 30 | 18 | 6 | 6 | 66:33 | 33 | 60 |
| 4 |
|
FC Schalke 04 | 30 | 14 | 12 | 4 | 41:27 | 14 | 54 |
| 5 |
|
Bayer Leverkusen | 30 | 12 | 8 | 10 | 53:44 | 9 | 44 |
| 6 |
|
Hertha BSC | 30 | 11 | 11 | 8 | 44:37 | 7 | 44 |
| 7 |
|
VfB Stuttgart | 30 | 8 | 16 | 6 | 32:30 | 2 | 40 |
| 8 |
|
Borussia Dortmund | 30 | 9 | 11 | 10 | 37:36 | 1 | 38 |
| 9 |
|
1. FC Nürnberg | 30 | 10 | 7 | 13 | 39:44 | -5 | 37 |
| 10 |
|
Bor. Mönchengladbach | 30 | 9 | 10 | 11 | 34:41 | -7 | 37 |
| 11 |
|
Arminia Bielefeld | 30 | 10 | 7 | 13 | 29:37 | -8 | 37 |
| 12 |
|
Hannover 96 | 30 | 7 | 15 | 8 | 38:40 | -2 | 36 |
| 13 |
|
Eintracht Frankfurt | 30 | 8 | 7 | 15 | 37:46 | -9 | 31 |
| 14 |
|
1. FSV Mainz 05 | 30 | 7 | 9 | 14 | 40:45 | -5 | 30 |
| 15 |
|
VfL Wolfsburg | 30 | 6 | 12 | 12 | 29:48 | -19 | 30 |
| 16 |
|
1. FC Kaiserslautern | 30 | 7 | 6 | 17 | 41:66 | -25 | 27 |
| 17 |
|
1. FC Köln | 30 | 5 | 9 | 16 | 42:61 | -19 | 24 |
| 18 |
|
MSV Duisburg | 30 | 4 | 11 | 15 | 28:55 | -27 | 23 |
