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| 26.11.2021 | 20:30 | VfB Stuttgart | - | 1. FSV Mainz 05 | 2:1 (1:1) | |
| 27.11.2021 | 15:30 | VfL Wolfsburg | - | Borussia Dortmund | 1:3 (1:1) | |
| 15:30 | Hertha BSC | - | FC Augsburg | 1:1 (1:0) | ||
| 15:30 | 1. FC Köln | - | Bor. Mönchengladbach | 4:1 (0:0) | ||
| 15:30 | VfL Bochum | - | SC Freiburg | 2:1 (0:0) | ||
| 15:30 | SpVgg Greuther Fürth | - | 1899 Hoffenheim | 3:6 (1:2) | ||
| 18:30 | Bayern München | - | Arminia Bielefeld | 1:0 (0:0) | ||
| 28.11.2021 | 15:30 | Eintracht Frankfurt | - | 1. FC Union Berlin | 2:1 (1:0) | |
| 17:30 | RB Leipzig | - | Bayer Leverkusen | 1:3 (0:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 13 | 10 | 1 | 2 | 42:13 | 29 | 31 |
| 2 |
|
Borussia Dortmund | 13 | 10 | 0 | 3 | 33:19 | 14 | 30 |
| 3 |
|
Bayer Leverkusen | 13 | 7 | 3 | 3 | 28:18 | 10 | 24 |
| 4 |
|
SC Freiburg | 13 | 6 | 4 | 3 | 19:13 | 6 | 22 |
| 5 |
|
1899 Hoffenheim | 13 | 6 | 2 | 5 | 27:20 | 7 | 20 |
| 6 |
|
1. FC Union Berlin | 13 | 5 | 5 | 3 | 20:19 | 1 | 20 |
| 7 |
|
VfL Wolfsburg | 13 | 6 | 2 | 5 | 15:17 | -2 | 20 |
| 8 |
|
RB Leipzig | 13 | 5 | 3 | 5 | 24:16 | 8 | 18 |
| 9 |
|
1. FSV Mainz 05 | 13 | 5 | 3 | 5 | 17:14 | 3 | 18 |
| 10 |
|
1. FC Köln | 13 | 4 | 6 | 3 | 22:22 | 0 | 18 |
| 11 |
|
Bor. Mönchengladbach | 13 | 5 | 3 | 5 | 18:18 | 0 | 18 |
| 12 |
|
Eintracht Frankfurt | 13 | 4 | 6 | 3 | 16:17 | -1 | 18 |
| 13 |
|
VfL Bochum | 13 | 5 | 1 | 7 | 12:20 | -8 | 16 |
| 14 |
|
Hertha BSC | 13 | 4 | 2 | 7 | 13:27 | -14 | 14 |
| 15 |
|
VfB Stuttgart | 13 | 3 | 4 | 6 | 18:23 | -5 | 13 |
| 16 |
|
FC Augsburg | 13 | 3 | 4 | 6 | 12:22 | -10 | 13 |
| 17 |
|
Arminia Bielefeld | 13 | 1 | 6 | 6 | 9:19 | -10 | 9 |
| 18 |
|
SpVgg Greuther Fürth | 13 | 0 | 1 | 12 | 11:39 | -28 | 1 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
