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| 15.04.2022 | 19:00 | Spezia Calcio | - | Inter | 1:3 (0:1) | |
| 21:00 | AC Milan | - | Genoa CFC | 2:0 (1:0) | ||
| 16.04.2022 | 12:30 | Cagliari Calcio | - | Sassuolo Calcio | 1:0 (1:0) | |
| 14:30 | Sampdoria | - | US Salernitana 1919 | 1:2 (1:2) | ||
| 14:30 | Udinese Calcio | - | Empoli FC | 4:1 (1:0) | ||
| 16:30 | ACF Fiorentina | - | Venezia FC | 1:0 (1:0) | ||
| 18:30 | Juventus | - | Bologna FC | 1:1 (0:0) | ||
| 20:45 | Lazio Roma | - | Torino FC | 1:1 (0:0) | ||
| 18.04.2022 | 19:00 | SSC Napoli | - | AS Roma | 1:1 (1:0) | |
| 21:00 | Atalanta | - | Hellas Verona | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AC Milan | 33 | 21 | 8 | 4 | 58:29 | 29 | 71 |
| 2 |
|
Inter | 33 | 20 | 9 | 4 | 69:27 | 42 | 69 |
| 3 |
|
SSC Napoli | 33 | 20 | 7 | 6 | 59:27 | 32 | 67 |
| 4 |
|
Juventus | 33 | 18 | 9 | 6 | 50:29 | 21 | 63 |
| 5 |
|
AS Roma | 33 | 17 | 7 | 9 | 54:37 | 17 | 58 |
| 6 |
|
Lazio Roma | 33 | 16 | 8 | 9 | 65:48 | 17 | 56 |
| 7 |
|
ACF Fiorentina | 33 | 17 | 5 | 11 | 53:44 | 9 | 56 |
| 8 |
|
Atalanta | 33 | 14 | 10 | 9 | 58:42 | 16 | 52 |
| 9 |
|
Hellas Verona | 33 | 13 | 9 | 11 | 58:50 | 8 | 48 |
| 10 |
|
Sassuolo Calcio | 33 | 12 | 10 | 11 | 58:53 | 5 | 46 |
| 11 |
|
Udinese Calcio | 33 | 10 | 12 | 11 | 51:50 | 1 | 42 |
| 12 |
|
Torino FC | 33 | 10 | 11 | 12 | 40:35 | 5 | 41 |
| 13 |
|
Bologna FC | 33 | 11 | 8 | 14 | 37:46 | -9 | 41 |
| 14 |
|
Empoli FC | 33 | 8 | 10 | 15 | 42:60 | -18 | 34 |
| 15 |
|
Spezia Calcio | 33 | 9 | 6 | 18 | 33:57 | -24 | 33 |
| 16 |
|
Sampdoria | 33 | 8 | 5 | 20 | 40:56 | -16 | 29 |
| 17 |
|
Cagliari Calcio | 33 | 6 | 10 | 17 | 31:61 | -30 | 28 |
| 18 |
|
US Salernitana 1919 | 33 | 6 | 7 | 20 | 28:70 | -42 | 25 |
| 19 |
|
Genoa CFC | 33 | 2 | 16 | 15 | 24:54 | -30 | 22 |
| 20 |
|
Venezia FC | 33 | 5 | 7 | 21 | 27:60 | -33 | 22 |
| Champions League | |
| Europa League | |
| Degradatie |
