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| 23.04.2022 | 15:00 | Torino FC | - | Spezia Calcio | 2:1 (1:0) | |
| 15:00 | Venezia FC | - | Atalanta | 1:3 (0:1) | ||
| 18:00 | Inter | - | AS Roma | 3:1 (2:0) | ||
| 20:45 | Hellas Verona | - | Sampdoria | 1:1 (0:1) | ||
| 24.04.2022 | 12:30 | US Salernitana 1919 | - | ACF Fiorentina | 2:1 (1:0) | |
| 15:00 | Bologna FC | - | Udinese Calcio | 2:2 (1:1) | ||
| 15:00 | Empoli FC | - | SSC Napoli | 3:2 (0:1) | ||
| 18:00 | Genoa CFC | - | Cagliari Calcio | 1:0 (0:0) | ||
| 20:45 | Lazio Roma | - | AC Milan | 1:2 (1:0) | ||
| 25.04.2022 | 20:45 | Sassuolo Calcio | - | Juventus | 1:2 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AC Milan | 34 | 22 | 8 | 4 | 60:30 | 30 | 74 |
| 2 |
|
Inter | 34 | 21 | 9 | 4 | 72:28 | 44 | 72 |
| 3 |
|
SSC Napoli | 34 | 20 | 7 | 7 | 61:30 | 31 | 67 |
| 4 |
|
Juventus | 34 | 19 | 9 | 6 | 52:30 | 22 | 66 |
| 5 |
|
AS Roma | 34 | 17 | 7 | 10 | 55:40 | 15 | 58 |
| 6 |
|
Lazio Roma | 34 | 16 | 8 | 10 | 66:50 | 16 | 56 |
| 7 |
|
ACF Fiorentina | 34 | 17 | 5 | 12 | 54:46 | 8 | 56 |
| 8 |
|
Atalanta | 34 | 15 | 10 | 9 | 61:43 | 18 | 55 |
| 9 |
|
Hellas Verona | 34 | 13 | 10 | 11 | 59:51 | 8 | 49 |
| 10 |
|
Sassuolo Calcio | 34 | 12 | 10 | 12 | 59:55 | 4 | 46 |
| 11 |
|
Torino FC | 34 | 11 | 11 | 12 | 42:36 | 6 | 44 |
| 12 |
|
Udinese Calcio | 34 | 10 | 13 | 11 | 53:52 | 1 | 43 |
| 13 |
|
Bologna FC | 34 | 11 | 9 | 14 | 39:48 | -9 | 42 |
| 14 |
|
Empoli FC | 34 | 9 | 10 | 15 | 45:62 | -17 | 37 |
| 15 |
|
Spezia Calcio | 34 | 9 | 6 | 19 | 34:59 | -25 | 33 |
| 16 |
|
Sampdoria | 34 | 8 | 6 | 20 | 41:57 | -16 | 30 |
| 17 |
|
Cagliari Calcio | 34 | 6 | 10 | 18 | 31:62 | -31 | 28 |
| 18 |
|
US Salernitana 1919 | 34 | 7 | 7 | 20 | 30:71 | -41 | 28 |
| 19 |
|
Genoa CFC | 34 | 3 | 16 | 15 | 25:54 | -29 | 25 |
| 20 |
|
Venezia FC | 34 | 5 | 7 | 22 | 28:63 | -35 | 22 |
| Champions League | |
| Europa League | |
| Degradatie |
