| 9. Ronde | 08.10.2021 | Real Valladolid | - | Málaga CF | 1:1 | ||||
| 10. Ronde | 17.10.2021 | CD Leganés | - | Real Valladolid | 0:2 | ||||
| 11. Ronde | 20.10.2021 | Real Valladolid | - | UD Ibiza | 1:1 |  |
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| 12. Ronde | 23.10.2021 | Sporting Gijón | - | Real Valladolid | 1:2 | ||||
| 13. Ronde | 31.10.2021 | Real Valladolid | - | SD Eibar | 2:0 | ||||
| 14. Ronde | 03.11.2021 | SD Amorebieta | - | Real Valladolid | 4:1 | ||||
| 15. Ronde | 06.11.2021 | Real Valladolid | - | CD Mirandés | 3:1 | ||||
| 16. Ronde | 13.11.2021 | Real Valladolid | - | CF Fuenlabrada | 3:0 | ||||
| 17. Ronde | 20.11.2021 | UD Almería | - | Real Valladolid | 3:1 | ||||
| 18. Ronde | 27.11.2021 | Real Valladolid | - | FC Cartagena | 2:0 | ||||
| 19. Ronde | 03.12.2021 | SD Huesca | - | Real Valladolid | 3:2 |  |
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| 20. Ronde | 12.12.2021 | Real Valladolid | - | Real Oviedo | 2:1 | |
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| 21. Ronde | 19.12.2021 | Real Sociedad B | - | Real Valladolid | 0:2 | ||||
| 24. Ronde | 22.01.2022 | Real Zaragoza | - | Real Valladolid | 0:0 |
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