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| 10.01.1981 | FC 08 Homburg | - | VfR Bürstadt | 1:1 (1:1) | ||
| SSV Ulm 1846 | - | Freiburger FC | 2:2 (0:0) | |||
| Waldhof Mannheim | - | Hessen Kassel | 0:0 (0:0) | |||
| SpVgg Fürth | - | ESV Ingolstadt | 3:0 (2:0) | |||
| SV Darmstadt 98 | - | VfB Eppingen | 2:0 (1:0) | |||
| 22.01.1981 | SpVgg Bayreuth | - | Kickers Offenbach | 0:0 (0:0) | ||
| 31.01.1981 | FSV Frankfurt | - | Eintracht Trier | 3:0 (0:0) | ||
| Wormatia Worms | - | Borussia Neunkirchen | 3:1 (2:1) | |||
| 1. FC Saarbrücken | - | Stuttgarter Kickers | 2:1 (0:0) | |||
| 28.02.1981 | SC Freiburg | - | FC Augsburg | 1:0 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Darmstadt 98 | 21 | 15 | 4 | 2 | 61:26 | 35 | 34:8 |
| 2 |
|
Stuttgarter Kickers | 21 | 10 | 5 | 6 | 46:25 | 21 | 25:17 |
| 3 |
|
Kickers Offenbach | 21 | 9 | 7 | 5 | 48:29 | 19 | 25:17 |
| 4 |
|
Hessen Kassel | 21 | 7 | 11 | 3 | 38:22 | 16 | 25:17 |
| 5 |
|
SC Freiburg | 21 | 10 | 5 | 6 | 28:17 | 11 | 25:17 |
| 6 |
|
Waldhof Mannheim | 21 | 10 | 4 | 7 | 34:25 | 9 | 24:18 |
| 7 |
|
Eintracht Trier | 21 | 9 | 6 | 6 | 29:29 | 0 | 24:18 |
| 8 |
|
SpVgg Bayreuth | 21 | 8 | 7 | 6 | 32:22 | 10 | 23:19 |
| 9 |
|
SSV Ulm 1846 | 21 | 9 | 4 | 8 | 31:28 | 3 | 22:20 |
| 10 |
|
FSV Frankfurt | 21 | 9 | 4 | 8 | 30:30 | 0 | 22:20 |
| 11 |
|
Freiburger FC | 21 | 7 | 6 | 8 | 41:44 | -3 | 20:22 |
| 12 |
|
FC 08 Homburg | 21 | 7 | 6 | 8 | 34:44 | -10 | 20:22 |
| 13 |
|
VfR Bürstadt | 21 | 7 | 5 | 9 | 27:37 | -10 | 19:23 |
| 14 |
|
SpVgg Fürth | 21 | 8 | 2 | 11 | 32:33 | -1 | 18:24 |
| 15 |
|
Wormatia Worms | 21 | 8 | 1 | 12 | 32:49 | -17 | 17:25 |
| 16 |
|
FC Augsburg | 21 | 6 | 4 | 11 | 36:51 | -15 | 16:26 |
| 17 |
|
VfB Eppingen | 21 | 6 | 4 | 11 | 31:47 | -16 | 16:26 |
| 18 |
|
ESV Ingolstadt | 21 | 7 | 2 | 12 | 38:59 | -21 | 16:26 |
| 19 |
|
1. FC Saarbrücken | 21 | 5 | 5 | 11 | 26:35 | -9 | 15:27 |
| 20 |
|
Borussia Neunkirchen | 21 | 3 | 8 | 10 | 25:47 | -22 | 14:28 |
