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| 12.03.2022 | 15:30 | 1899 Hoffenheim | - | Bayern München | 1:1 (1:1) | |
| 15:30 | SC Freiburg | - | VfL Wolfsburg | 3:2 (2:0) | ||
| 15:30 | 1. FC Union Berlin | - | VfB Stuttgart | 1:1 (1:0) | ||
| 18:30 | Bor. Mönchengladbach | - | Hertha BSC | 2:0 (1:0) | ||
| 13.03.2022 | 15:30 | Bayer Leverkusen | - | 1. FC Köln | 0:1 (0:0) | |
| 17:30 | Borussia Dortmund | - | Arminia Bielefeld | 1:0 (1:0) | ||
| 17:30 | Eintracht Frankfurt | - | VfL Bochum | 2:1 (0:1) | ||
| 19:30 | SpVgg Greuther Fürth | - | RB Leipzig | 1:6 (1:4) | ||
| 06.04.2022 | 18:30 | FC Augsburg | - | 1. FSV Mainz 05 | 2:1 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 26 | 19 | 3 | 4 | 77:28 | 49 | 60 |
| 2 |
|
Borussia Dortmund | 26 | 18 | 2 | 6 | 66:37 | 29 | 56 |
| 3 |
|
Bayer Leverkusen | 26 | 13 | 6 | 7 | 64:41 | 23 | 45 |
| 4 |
|
RB Leipzig | 26 | 13 | 5 | 8 | 57:30 | 27 | 44 |
| 5 |
|
SC Freiburg | 26 | 12 | 8 | 6 | 43:29 | 14 | 44 |
| 6 |
|
1899 Hoffenheim | 26 | 13 | 5 | 8 | 49:37 | 12 | 44 |
| 7 |
|
1. FC Köln | 26 | 10 | 9 | 7 | 37:39 | -2 | 39 |
| 8 |
|
1. FC Union Berlin | 26 | 10 | 8 | 8 | 33:34 | -1 | 38 |
| 9 |
|
Eintracht Frankfurt | 26 | 10 | 7 | 9 | 39:38 | 1 | 37 |
| 10 |
|
1. FSV Mainz 05 | 26 | 10 | 4 | 12 | 36:32 | 4 | 34 |
| 11 |
|
VfL Bochum | 26 | 9 | 5 | 12 | 28:37 | -9 | 32 |
| 12 |
|
VfL Wolfsburg | 26 | 9 | 4 | 13 | 29:40 | -11 | 31 |
| 13 |
|
Bor. Mönchengladbach | 26 | 8 | 6 | 12 | 36:51 | -15 | 30 |
| 14 |
|
FC Augsburg | 26 | 7 | 8 | 11 | 29:42 | -13 | 29 |
| 15 |
|
Arminia Bielefeld | 26 | 5 | 10 | 11 | 22:34 | -12 | 25 |
| 16 |
|
VfB Stuttgart | 26 | 5 | 8 | 13 | 32:48 | -16 | 23 |
| 17 |
|
Hertha BSC | 26 | 6 | 5 | 15 | 26:60 | -34 | 23 |
| 18 |
|
SpVgg Greuther Fürth | 26 | 3 | 5 | 18 | 24:70 | -46 | 14 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
