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| 18.03.2022 | 20:30 | VfL Bochum | - | Bor. Mönchengladbach | 0:2 (0:0) Toeg. | |
| 19.03.2022 | 15:30 | SpVgg Greuther Fürth | - | SC Freiburg | 0:0 (0:0) | |
| 15:30 | Hertha BSC | - | 1899 Hoffenheim | 3:0 (1:0) | ||
| 15:30 | VfB Stuttgart | - | FC Augsburg | 3:2 (1:2) | ||
| 15:30 | 1. FSV Mainz 05 | - | Arminia Bielefeld | 4:0 (1:0) | ||
| 18:30 | Bayern München | - | 1. FC Union Berlin | 4:0 (3:0) | ||
| 20.03.2022 | 15:30 | RB Leipzig | - | Eintracht Frankfurt | 0:0 (0:0) | |
| 17:30 | VfL Wolfsburg | - | Bayer Leverkusen | 0:2 (0:0) | ||
| 19:30 | 1. FC Köln | - | Borussia Dortmund | 1:1 (1:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 27 | 20 | 3 | 4 | 81:28 | 53 | 63 |
| 2 |
|
Borussia Dortmund | 27 | 18 | 3 | 6 | 67:38 | 29 | 57 |
| 3 |
|
Bayer Leverkusen | 27 | 14 | 6 | 7 | 66:41 | 25 | 48 |
| 4 |
|
RB Leipzig | 27 | 13 | 6 | 8 | 57:30 | 27 | 45 |
| 5 |
|
SC Freiburg | 27 | 12 | 9 | 6 | 43:29 | 14 | 45 |
| 6 |
|
1899 Hoffenheim | 27 | 13 | 5 | 9 | 49:40 | 9 | 44 |
| 7 |
|
1. FC Köln | 27 | 10 | 10 | 7 | 38:40 | -2 | 40 |
| 8 |
|
Eintracht Frankfurt | 27 | 10 | 8 | 9 | 39:38 | 1 | 38 |
| 9 |
|
1. FC Union Berlin | 27 | 10 | 8 | 9 | 33:38 | -5 | 38 |
| 10 |
|
1. FSV Mainz 05 | 27 | 11 | 4 | 12 | 40:32 | 8 | 37 |
| 11 |
|
Bor. Mönchengladbach | 27 | 9 | 6 | 12 | 38:51 | -13 | 33 |
| 12 |
|
VfL Bochum | 27 | 9 | 5 | 13 | 28:39 | -11 | 32 |
| 13 |
|
VfL Wolfsburg | 27 | 9 | 4 | 14 | 29:42 | -13 | 31 |
| 14 |
|
FC Augsburg | 27 | 7 | 8 | 12 | 31:45 | -14 | 29 |
| 15 |
|
VfB Stuttgart | 27 | 6 | 8 | 13 | 35:50 | -15 | 26 |
| 16 |
|
Hertha BSC | 27 | 7 | 5 | 15 | 29:60 | -31 | 26 |
| 17 |
|
Arminia Bielefeld | 27 | 5 | 10 | 12 | 22:38 | -16 | 25 |
| 18 |
|
SpVgg Greuther Fürth | 27 | 3 | 6 | 18 | 24:70 | -46 | 15 |
| Champions League | |
| Europa League | |
| Promotie en degradatie | |
| Degradatie |
