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| 11.03.2016 | 18:30 | FC St. Pauli | - | SC Paderborn 07 | 3:4 (0:2) | |
| 18:30 | SpVgg Greuther Fürth | - | Eintracht Braunschweig | 3:0 (1:0) | ||
| 18:30 | Arminia Bielefeld | - | 1. FC Nürnberg | 0:4 (0:0) | ||
| 12.03.2016 | 13:00 | SV Sandhausen | - | Fortuna Düsseldorf | 1:0 (0:0) | |
| 13:00 | MSV Duisburg | - | 1. FC Union Berlin | 2:1 (0:0) | ||
| 13.03.2016 | 13:30 | FSV Frankfurt | - | SC Freiburg | 1:3 (0:1) | |
| 13:30 | RB Leipzig | - | TSV 1860 München | 2:1 (0:0) | ||
| 13:30 | Karlsruher SC | - | 1. FC Heidenheim 1846 | 0:0 (0:0) | ||
| 14.03.2016 | 20:15 | 1. FC Kaiserslautern | - | VfL Bochum | 0:2 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RB Leipzig | 26 | 17 | 5 | 4 | 43:23 | 20 | 56 |
| 2 |
|
SC Freiburg | 26 | 16 | 5 | 5 | 57:29 | 28 | 53 |
| 3 |
|
1. FC Nürnberg | 26 | 14 | 8 | 4 | 51:31 | 20 | 50 |
| 4 |
|
VfL Bochum | 26 | 11 | 10 | 5 | 42:25 | 17 | 43 |
| 5 |
|
FC St. Pauli | 26 | 12 | 6 | 8 | 32:29 | 3 | 42 |
| 6 |
|
1. FC Heidenheim 1846 | 26 | 9 | 9 | 8 | 31:28 | 3 | 36 |
| 7 |
|
SpVgg Greuther Fürth | 26 | 10 | 6 | 10 | 35:39 | -4 | 36 |
| 8 |
|
Eintracht Braunschweig | 26 | 9 | 8 | 9 | 31:24 | 7 | 35 |
| 9 |
|
Karlsruher SC | 26 | 9 | 8 | 9 | 25:30 | -5 | 35 |
| 10 |
|
1. FC Union Berlin | 26 | 8 | 9 | 9 | 43:40 | 3 | 33 |
| 11 |
|
SV Sandhausen | 26 | 10 | 6 | 10 | 34:34 | 0 | 33 |
| 12 |
|
1. FC Kaiserslautern | 26 | 8 | 7 | 11 | 33:35 | -2 | 31 |
| 13 |
|
Arminia Bielefeld | 26 | 5 | 14 | 7 | 25:32 | -7 | 29 |
| 14 |
|
FSV Frankfurt | 26 | 7 | 7 | 12 | 27:41 | -14 | 28 |
| 15 |
|
TSV 1860 München | 26 | 5 | 9 | 12 | 24:37 | -13 | 24 |
| 16 |
|
Fortuna Düsseldorf | 26 | 6 | 6 | 14 | 21:35 | -14 | 24 |
| 17 |
|
SC Paderborn 07 | 26 | 5 | 8 | 13 | 23:44 | -21 | 23 |
| 18 |
|
MSV Duisburg | 26 | 3 | 9 | 14 | 23:44 | -21 | 18 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
