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| 22.04.2016 | 18:30 | VfL Bochum | - | Karlsruher SC | 1:1 (0:0) | |
| 18:30 | Fortuna Düsseldorf | - | FC St. Pauli | 1:1 (1:0) | ||
| 18:30 | SC Freiburg | - | MSV Duisburg | 3:0 (2:0) | ||
| 23.04.2016 | 13:00 | 1. FC Heidenheim 1846 | - | SC Paderborn 07 | 1:1 (1:1) | |
| 13:00 | 1. FC Nürnberg | - | 1. FC Union Berlin | 6:2 (0:2) | ||
| 24.04.2016 | 13:30 | TSV 1860 München | - | Eintracht Braunschweig | 1:0 (0:0) | |
| 13:30 | Arminia Bielefeld | - | SpVgg Greuther Fürth | 4:2 (1:1) | ||
| 13:30 | SV Sandhausen | - | FSV Frankfurt | 1:0 (0:0) | ||
| 25.04.2016 | 20:15 | 1. FC Kaiserslautern | - | RB Leipzig | 1:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg | 31 | 20 | 6 | 5 | 70:36 | 34 | 66 |
| 2 |
|
RB Leipzig | 31 | 19 | 6 | 6 | 51:30 | 21 | 63 |
| 3 |
|
1. FC Nürnberg | 31 | 17 | 8 | 6 | 65:38 | 27 | 59 |
| 4 |
|
FC St. Pauli | 31 | 14 | 8 | 9 | 40:34 | 6 | 50 |
| 5 |
|
VfL Bochum | 31 | 12 | 12 | 7 | 50:34 | 16 | 48 |
| 6 |
|
1. FC Union Berlin | 31 | 11 | 10 | 10 | 53:47 | 6 | 43 |
| 7 |
|
Karlsruher SC | 31 | 11 | 10 | 10 | 31:34 | -3 | 43 |
| 8 |
|
SpVgg Greuther Fürth | 31 | 12 | 7 | 12 | 45:49 | -4 | 43 |
| 9 |
|
1. FC Heidenheim 1846 | 31 | 10 | 12 | 9 | 38:34 | 4 | 42 |
| 10 |
|
Eintracht Braunschweig | 31 | 10 | 10 | 11 | 38:33 | 5 | 40 |
| 11 |
|
1. FC Kaiserslautern | 31 | 10 | 9 | 12 | 40:40 | 0 | 39 |
| 12 |
|
SV Sandhausen | 31 | 12 | 6 | 13 | 37:42 | -5 | 39 |
| 13 |
|
Arminia Bielefeld | 31 | 7 | 16 | 8 | 34:37 | -3 | 37 |
| 14 |
|
Fortuna Düsseldorf | 31 | 7 | 8 | 16 | 28:45 | -17 | 29 |
| 15 |
|
FSV Frankfurt | 31 | 7 | 8 | 16 | 30:53 | -23 | 29 |
| 16 |
|
TSV 1860 München | 31 | 6 | 10 | 15 | 28:44 | -16 | 28 |
| 17 |
|
SC Paderborn 07 | 31 | 6 | 10 | 15 | 27:51 | -24 | 28 |
| 18 |
|
MSV Duisburg | 31 | 5 | 10 | 16 | 27:51 | -24 | 25 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
