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| 26.11.2021 | 18:30 | Fortuna Düsseldorf | - | 1. FC Heidenheim 1846 | 0:1 (0:0) | |
| 18:30 | Jahn Regensburg | - | Dynamo Dresden | 3:1 (1:0) | ||
| 27.11.2021 | 13:30 | FC Schalke 04 | - | SV Sandhausen | 5:2 (0:0) | |
| 13:30 | Karlsruher SC | - | Hannover 96 | 4:0 (3:0) | ||
| 13:30 | Erzgebirge Aue | - | SV Darmstadt 98 | 1:2 (0:0) | ||
| 20:30 | Holstein Kiel | - | Werder Bremen | 2:1 (1:0) | ||
| 28.11.2021 | 13:30 | Hamburger SV | - | FC Ingolstadt 04 | 3:0 (2:0) | |
| 13:30 | SC Paderborn 07 | - | Hansa Rostock | 1:1 (0:1) | ||
| 13:30 | 1. FC Nürnberg | - | FC St. Pauli | 2:3 (1:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC St. Pauli | 15 | 10 | 2 | 3 | 34:18 | 16 | 32 |
| 2 |
|
SV Darmstadt 98 | 15 | 9 | 2 | 4 | 37:17 | 20 | 29 |
| 3 |
|
Jahn Regensburg | 15 | 8 | 4 | 3 | 33:20 | 13 | 28 |
| 4 |
|
SC Paderborn 07 | 15 | 7 | 5 | 3 | 29:17 | 12 | 26 |
| 5 |
|
Hamburger SV | 15 | 6 | 8 | 1 | 27:16 | 11 | 26 |
| 6 |
|
FC Schalke 04 | 15 | 8 | 2 | 5 | 28:19 | 9 | 26 |
| 7 |
|
1. FC Nürnberg | 15 | 6 | 6 | 3 | 21:15 | 6 | 24 |
| 8 |
|
1. FC Heidenheim 1846 | 15 | 7 | 3 | 5 | 16:20 | -4 | 24 |
| 9 |
|
Karlsruher SC | 15 | 5 | 6 | 4 | 25:21 | 4 | 21 |
| 10 |
|
Werder Bremen | 15 | 5 | 5 | 5 | 21:22 | -1 | 20 |
| 11 |
|
Hansa Rostock | 15 | 5 | 3 | 7 | 18:25 | -7 | 18 |
| 12 |
|
Holstein Kiel | 15 | 4 | 5 | 6 | 17:26 | -9 | 17 |
| 13 |
|
Fortuna Düsseldorf | 15 | 4 | 4 | 7 | 19:22 | -3 | 16 |
| 14 |
|
Dynamo Dresden | 15 | 5 | 1 | 9 | 16:21 | -5 | 16 |
| 15 |
|
Erzgebirge Aue | 15 | 3 | 5 | 7 | 14:22 | -8 | 14 |
| 16 |
|
Hannover 96 | 15 | 3 | 5 | 7 | 10:22 | -12 | 14 |
| 17 |
|
SV Sandhausen | 15 | 3 | 3 | 9 | 16:33 | -17 | 12 |
| 18 |
|
FC Ingolstadt 04 | 15 | 1 | 3 | 11 | 9:34 | -25 | 6 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
