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| 03.12.2021 | 18:30 | Werder Bremen | - | Erzgebirge Aue | 4:0 (2:0) | |
| 18:30 | SV Darmstadt 98 | - | Fortuna Düsseldorf | 1:3 (0:2) | ||
| 04.12.2021 | 13:30 | 1. FC Nürnberg | - | Holstein Kiel | 2:1 (1:0) | |
| 13:30 | SV Sandhausen | - | SC Paderborn 07 | 1:1 (0:1) | ||
| 13:30 | Hansa Rostock | - | FC Ingolstadt 04 | 1:1 (0:1) | ||
| 20:30 | FC St. Pauli | - | FC Schalke 04 | 2:1 (2:0) | ||
| 05.12.2021 | 13:30 | 1. FC Heidenheim 1846 | - | Jahn Regensburg | 3:0 (1:0) | |
| 13:30 | Hannover 96 | - | Hamburger SV | 1:0 (1:0) | ||
| 13:30 | Dynamo Dresden | - | Karlsruher SC | 3:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC St. Pauli | 16 | 11 | 2 | 3 | 36:19 | 17 | 35 |
| 2 |
|
SV Darmstadt 98 | 16 | 9 | 2 | 5 | 38:20 | 18 | 29 |
| 3 |
|
Jahn Regensburg | 16 | 8 | 4 | 4 | 33:23 | 10 | 28 |
| 4 |
|
SC Paderborn 07 | 16 | 7 | 6 | 3 | 30:18 | 12 | 27 |
| 5 |
|
1. FC Nürnberg | 16 | 7 | 6 | 3 | 23:16 | 7 | 27 |
| 6 |
|
1. FC Heidenheim 1846 | 16 | 8 | 3 | 5 | 19:20 | -1 | 27 |
| 7 |
|
Hamburger SV | 16 | 6 | 8 | 2 | 27:17 | 10 | 26 |
| 8 |
|
FC Schalke 04 | 16 | 8 | 2 | 6 | 29:21 | 8 | 26 |
| 9 |
|
Werder Bremen | 16 | 6 | 5 | 5 | 25:22 | 3 | 23 |
| 10 |
|
Karlsruher SC | 16 | 5 | 6 | 5 | 26:24 | 2 | 21 |
| 11 |
|
Fortuna Düsseldorf | 16 | 5 | 4 | 7 | 22:23 | -1 | 19 |
| 12 |
|
Dynamo Dresden | 16 | 6 | 1 | 9 | 19:22 | -3 | 19 |
| 13 |
|
Hansa Rostock | 16 | 5 | 4 | 7 | 19:26 | -7 | 19 |
| 14 |
|
Holstein Kiel | 16 | 4 | 5 | 7 | 18:28 | -10 | 17 |
| 15 |
|
Hannover 96 | 16 | 4 | 5 | 7 | 11:22 | -11 | 17 |
| 16 |
|
Erzgebirge Aue | 16 | 3 | 5 | 8 | 14:26 | -12 | 14 |
| 17 |
|
SV Sandhausen | 16 | 3 | 4 | 9 | 17:34 | -17 | 13 |
| 18 |
|
FC Ingolstadt 04 | 16 | 1 | 4 | 11 | 10:35 | -25 | 7 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
