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| U | Slavia Sofia | - | Feyenoord | 3:2 (1:1) | ||
| R | Feyenoord | - | Slavia Sofia | 4:0 (1:0) | ||
| U: 04.03.1981 | R: 18.03.1981 | Winnaars: Feyenoord | ||||
| U | FC Carl Zeiss Jena | - | Newport County | 2:2 (1:1) | ||
| R | Newport County | - | FC Carl Zeiss Jena | 0:1 (0:1) | ||
| U: 04.03.1981 | R: 18.03.1981 | Winnaars: FC Carl Zeiss Jena | ||||
| U | Fortuna Düsseldorf | - | SL Benfica | 2:2 (2:1) | ||
| R | SL Benfica | - | Fortuna Düsseldorf | 1:0 (0:0) | ||
| U: 04.03.1981 | R: 18.03.1981 | Winnaars: SL Benfica | ||||
| U | West Ham United | - | Dinamo Tbilisi | 1:4 (0:2) | ||
| R | Dinamo Tbilisi | - | West Ham United | 0:1 (0:0) | ||
| U: 04.03.1981 | R: 18.03.1981 | Winnaars: Dinamo Tbilisi | ||||
