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| U | Shakhtar Donetsk | - | RSC Anderlecht | 3:1 (2:0) | ||
| R | RSC Anderlecht | - | Shakhtar Donetsk | 0:1 (0:0) | ||
| U: 10.03.2016 19:00 | R: 17.03.2016 21:05 | Winnaars: Shakhtar Donetsk | ||||
| U | FC Basel 1893 | - | Sevilla FC | 0:0 (0:0) | ||
| R | Sevilla FC | - | FC Basel 1893 | 3:0 (3:0) | ||
| U: 10.03.2016 19:00 | R: 17.03.2016 21:05 | Winnaars: Sevilla FC | ||||
| U | Borussia Dortmund | - | Tottenham Hotspur | 3:0 (1:0) | ||
| R | Tottenham Hotspur | - | Borussia Dortmund | 1:2 (0:1) | ||
| U: 10.03.2016 19:00 | R: 17.03.2016 21:05 | Winnaars: Borussia Dortmund | ||||
| U | Fenerbahçe | - | Sporting Braga | 1:0 (0:0) | ||
| R | Sporting Braga | - | Fenerbahçe | 4:1 (1:1) | ||
| U: 10.03.2016 19:00 | R: 17.03.2016 21:05 | Winnaars: Sporting Braga | ||||
| U | Villarreal CF | - | Bayer Leverkusen | 2:0 (1:0) | ||
| R | Bayer Leverkusen | - | Villarreal CF | 0:0 (0:0) | ||
| U: 10.03.2016 21:05 | R: 17.03.2016 19:00 | Winnaars: Villarreal CF | ||||
| U | Athletic Club | - | Valencia CF | 1:0 (1:0) | ||
| R | Valencia CF | - | Athletic Club | 2:1 (2:0) | ||
| U: 10.03.2016 21:05 | R: 17.03.2016 19:00 | Winnaars: Athletic Club | ||||
| U | Liverpool FC | - | Manchester United | 2:0 (1:0) | ||
| R | Manchester United | - | Liverpool FC | 1:1 (1:1) | ||
| U: 10.03.2016 21:05 | R: 17.03.2016 21:05 | Winnaars: Liverpool FC | ||||
| U | Sparta Praag | - | Lazio | 1:1 (1:1) | ||
| R | Lazio | - | Sparta Praag | 0:3 (0:3) | ||
| U: 10.03.2016 21:05 | R: 17.03.2016 19:00 | Winnaars: Sparta Praag | ||||
