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| U | FK Zalgiris | - | CFR Cluj | 1:2 (0:1) | ||
| R | CFR Cluj | - | FK Zalgiris | 5:1 (2:0) | ||
| U: 27.07.2005 17:30 | R: 03.08.2005 16:00 | Winnaars: CFR Cluj | ||||
| U | VfL Wolfsburg | - | RC Lens | 0:0 (0:0) | ||
| R | RC Lens | - | VfL Wolfsburg | 4:0 (1:0) | ||
| U: 27.07.2005 19:00 | R: 03.08.2005 19:00 | Winnaars: RC Lens | ||||
| U | Sigma Olomouc | - | Hamburger SV | 0:1 (0:0) | ||
| R | Hamburger SV | - | Sigma Olomouc | 3:0 (1:0) | ||
| U: 27.07.2005 20:15 | R: 03.08.2005 20:15 | Winnaars: Hamburger SV | ||||
| U | Deportivo La Coruña | - | Newcastle United | 2:1 (1:0) | ||
| R | Newcastle United | - | Deportivo La Coruña | 1:2 (1:1) | ||
| U: 27.07.2005 21:00 | R: 03.08.2005 20:45 | Winnaars: Deportivo La Coruña | ||||
| U | Lazio Roma | - | Olympique Marseille | 1:1 (1:0) | ||
| R | Olympique Marseille | - | Lazio Roma | 3:0 (0:0) | ||
| U: 27.07.2005 21:00 | R: 03.08.2005 21:00 | Winnaars: Olympique Marseille | ||||
| U | Valencia CF | - | Roda JC Kerkrade | 4:0 (2:0) | ||
| R | Roda JC Kerkrade | - | Valencia CF | 0:0 (0:0) | ||
| U: 27.07.2005 22:00 | R: 03.08.2005 20:00 | Winnaars: Valencia CF | ||||
