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| U | FC Porto | - | Spartak Moskou | 5:1 (1:0) | ||
| R | Spartak Moskou | - | FC Porto | 2:5 (0:2) | ||
| U: 07.04.2011 21:05 | R: 14.04.2011 19:00 | Winnaars: FC Porto | ||||
| U | SL Benfica | - | PSV | 4:1 (2:0) | ||
| R | PSV | - | SL Benfica | 2:2 (2:1) | ||
| U: 07.04.2011 21:05 | R: 14.04.2011 21:05 | Winnaars: SL Benfica | ||||
| U | Villarreal CF | - | FC Twente | 5:1 (3:0) | ||
| R | FC Twente | - | Villarreal CF | 1:3 (1:0) | ||
| U: 07.04.2011 21:05 | R: 14.04.2011 21:05 | Winnaars: Villarreal CF | ||||
| U | Dinamo Kiev | - | Sporting Braga | 1:1 (1:1) | ||
| R | Sporting Braga | - | Dinamo Kiev | 0:0 (0:0) | ||
| U: 07.04.2011 21:05 | R: 14.04.2011 21:05 | Winnaars: Sporting Braga | ||||
