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| U | VfL Wolfsburg | - | ACF Brescia | 3:0 (1:0) | ||
| R | ACF Brescia | - | VfL Wolfsburg | 0:3 (0:2) | ||
| U: 23.03.2016 18:00 | R: 30.03.2016 20:30 | Winnaars: VfL Wolfsburg | ||||
| U | FC Barcelona | - | Paris Saint-Germain | 0:0 (0:0) | ||
| R | Paris Saint-Germain | - | FC Barcelona | 1:0 (0:0) | ||
| U: 23.03.2016 18:30 | R: 30.03.2016 20:30 | Winnaars: Paris Saint-Germain | ||||
| U | Olympique Lyon | - | Slavia Praag | 9:1 (4:1) | ||
| R | Slavia Praag | - | Olympique Lyon | 0:0 (0:0) | ||
| U: 23.03.2016 19:00 | R: 30.03.2016 18:30 | Winnaars: Olympique Lyon | ||||
| U | FC Rosengård | - | 1. FFC Frankfurt | 0:1 (0:0) | ||
| R | 1. FFC Frankfurt | - | FC Rosengård | 5:4 (0:1, 0:1, 0:1) d.p. | ||
| U: 23.03.2016 20:00 | R: 30.03.2016 18:00 | Winnaars: 1. FFC Frankfurt | ||||
