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| U | Levski Sofia | - | FC Schalke 04 | 1:3 (1:0) | ||
| R | FC Schalke 04 | - | Levski Sofia | 1:1 (0:1) | ||
| U: 30.03.2006 19:00 | R: 06.04.2006 20:30 | Winnaars: FC Schalke 04 | ||||
| U | Rapid Bucureşti | - | FCSB | 1:1 (0:1) | ||
| R | FCSB | - | Rapid Bucureşti | 0:0 (0:0) | ||
| U: 30.03.2006 19:45 | R: 06.04.2006 19:30 | Winnaars: FCSB | ||||
| U | FC Basel | - | Middlesbrough FC | 2:0 (2:0) | ||
| R | Middlesbrough FC | - | FC Basel | 4:1 (1:1) | ||
| U: 30.03.2006 20:45 | R: 06.04.2006 21:00 | Winnaars: Middlesbrough FC | ||||
| U | Sevilla FC | - | Zenit St. Petersburg | 4:1 (1:1) | ||
| R | Zenit St. Petersburg | - | Sevilla FC | 1:1 (0:0) | ||
| U: 30.03.2006 21:00 | R: 06.04.2006 18:00 | Winnaars: Sevilla FC | ||||
