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| U | Shakhtar Donetsk | - | Olympique Marseille | 2:0 (1:0) | ||
| R | Olympique Marseille | - | Shakhtar Donetsk | 1:2 (1:1) | ||
| U: 09.04.2009 18:30 | R: 16.04.2009 20:45 | Winnaars: Shakhtar Donetsk | ||||
| U | Hamburger SV | - | Manchester City | 3:1 (1:1) | ||
| R | Manchester City | - | Hamburger SV | 2:1 (1:1) | ||
| U: 09.04.2009 20:45 | R: 16.04.2009 20:45 | Winnaars: Hamburger SV | ||||
| U | Paris Saint-Germain | - | Dinamo Kiev | 0:0 (0:0) | ||
| R | Dinamo Kiev | - | Paris Saint-Germain | 3:0 (2:0) | ||
| U: 09.04.2009 20:45 | R: 16.04.2009 18:30 | Winnaars: Dinamo Kiev | ||||
| U | Werder Bremen | - | Udinese Calcio | 3:1 (1:0) | ||
| R | Udinese Calcio | - | Werder Bremen | 3:3 (3:1) | ||
| U: 09.04.2009 20:45 | R: 16.04.2009 20:45 | Winnaars: Werder Bremen | ||||
