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| U | Metalist Kharkiv | - | Olympiakos | 0:1 (0:0) | ||
| R | Olympiakos | - | Metalist Kharkiv | 1:2 (1:0) | ||
| U: 08.03.2012 19:00 | R: 15.03.2012 21:05 | Winnaars: Metalist Kharkiv | ||||
| U | Sporting CP | - | Manchester City | 1:0 (0:0) | ||
| R | Manchester City | - | Sporting CP | 3:2 (0:2) | ||
| U: 08.03.2012 19:00 | R: 15.03.2012 21:05 | Winnaars: Sporting CP | ||||
| U | FC Twente | - | FC Schalke 04 | 1:0 (0:0) | ||
| R | FC Schalke 04 | - | FC Twente | 4:1 (1:1) | ||
| U: 08.03.2012 19:00 | R: 15.03.2012 21:05 | Winnaars: FC Schalke 04 | ||||
| U | Atlético Madrid | - | Beşiktaş | 3:1 (3:0) | ||
| R | Beşiktaş | - | Atlético Madrid | 0:3 (0:1) | ||
| U: 08.03.2012 19:00 | R: 15.03.2012 21:05 | Winnaars: Atlético Madrid | ||||
| U | Standard Luik | - | Hannover 96 | 2:2 (2:1) | ||
| R | Hannover 96 | - | Standard Luik | 4:0 (2:0) | ||
| U: 08.03.2012 21:05 | R: 15.03.2012 19:00 | Winnaars: Hannover 96 | ||||
| U | Valencia CF | - | PSV | 4:2 (3:0) | ||
| R | PSV | - | Valencia CF | 1:1 (0:0) | ||
| U: 08.03.2012 21:05 | R: 15.03.2012 19:00 | Winnaars: Valencia CF | ||||
| U | AZ Alkmaar | - | Udinese Calcio | 2:0 (0:0) | ||
| R | Udinese Calcio | - | AZ Alkmaar | 2:1 (2:1) | ||
| U: 08.03.2012 21:05 | R: 15.03.2012 19:00 | Winnaars: AZ Alkmaar | ||||
| U | Manchester United | - | Athletic Bilbao | 2:3 (1:1) | ||
| R | Athletic Bilbao | - | Manchester United | 2:1 (1:0) | ||
| U: 08.03.2012 21:05 | R: 15.03.2012 19:00 | Winnaars: Athletic Bilbao | ||||
