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| U | Hertha BSC | - | Fulham FC | 2:1 (1:0) | ||
| R | Fulham FC | - | Hertha BSC | 0:0 (0:0) | ||
| U: 26.11.2002 17:30 | R: 12.12.2002 18:00 | Winnaars: Hertha BSC | ||||
| U | Paris Saint-Germain | - | Boavista | 2:1 (2:0) | ||
| R | Boavista | - | Paris Saint-Germain | 1:0 (0:0) | ||
| U: 26.11.2002 18:00 | R: 12.12.2002 22:30 | Winnaars: Boavista | ||||
| U | Wisła Kraków | - | FC Schalke 04 | 1:1 (1:0) | ||
| R | FC Schalke 04 | - | Wisła Kraków | 1:4 (1:1) | ||
| U: 28.11.2002 17:30 | R: 10.12.2002 17:30 | Winnaars: Wisła Kraków | ||||
| U | Denizlispor | - | Olympique Lyon | 0:0 (0:0) | ||
| R | Olympique Lyon | - | Denizlispor | 0:1 (0:1) | ||
| U: 28.11.2002 18:00 | R: 12.12.2002 18:00 | Winnaars: Denizlispor | ||||
| U | Slovan Liberec | - | Panathinaikos | 2:2 (1:1) | ||
| R | Panathinaikos | - | Slovan Liberec | 1:0 (1:0) | ||
| U: 28.11.2002 18:30 | R: 12.12.2002 17:45 | Winnaars: Panathinaikos | ||||
| U | Beşiktaş | - | Dinamo Kiev | 3:1 (1:1) | ||
| R | Dinamo Kiev | - | Beşiktaş | 0:0 (0:0) | ||
| U: 28.11.2002 20:00 | R: 12.12.2002 19:00 | Winnaars: Beşiktaş | ||||
| U | Girondins Bordeaux | - | RSC Anderlecht | 0:2 (0:1) | ||
| R | RSC Anderlecht | - | Girondins Bordeaux | 2:2 (1:0) | ||
| U: 28.11.2002 20:00 | R: 12.12.2002 20:30 | Winnaars: RSC Anderlecht | ||||
| U | PAOK Saloniki | - | Slavia Praag | 1:0 (0:0) | ||
| R | Slavia Praag | - | PAOK Saloniki | 4:0 (1:0) | ||
| U: 28.11.2002 20:00 | R: 12.12.2002 20:30 | Winnaars: Slavia Praag | ||||
| U | AEK Athene | - | Maccabi Haifa | 4:0 (4:0) | ||
| R | Maccabi Haifa | - | AEK Athene | 1:4 (1:0) | ||
| U: 28.11.2002 20:15 | R: 12.12.2002 20:30 | Winnaars: AEK Athene | ||||
| U | Sturm Graz | - | Lazio Roma | 1:3 (1:0) | ||
| R | Lazio Roma | - | Sturm Graz | 0:1 (0:0) | ||
| U: 28.11.2002 20:30 | R: 12.12.2002 20:30 | Winnaars: Lazio Roma | ||||
| U | Club Brugge KV | - | VfB Stuttgart | 1:2 (1:0) | ||
| R | VfB Stuttgart | - | Club Brugge KV | 1:0 (0:0) | ||
| U: 28.11.2002 20:30 | R: 12.12.2002 20:30 | Winnaars: VfB Stuttgart | ||||
| U | Vitesse | - | Liverpool FC | 0:1 (0:1) | ||
| R | Liverpool FC | - | Vitesse | 1:0 (1:0) | ||
| U: 28.11.2002 20:45 | R: 12.12.2002 20:45 | Winnaars: Liverpool FC | ||||
| U | Celtic FC | - | Celta de Vigo | 1:0 (0:0) | ||
| R | Celta de Vigo | - | Celtic FC | 2:1 (1:1) | ||
| U: 28.11.2002 21:05 | R: 12.12.2002 21:05 | Winnaars: Celtic FC | ||||
| U | Real Betis | - | AJ Auxerre | 1:0 (1:0) | ||
| R | AJ Auxerre | - | Real Betis | 2:0 (1:0) | ||
| U: 28.11.2002 21:30 | R: 12.12.2002 19:30 | Winnaars: AJ Auxerre | ||||
| U | Málaga CF | - | Leeds United | 0:0 (0:0) | ||
| R | Leeds United | - | Málaga CF | 1:2 (1:1) | ||
| U: 28.11.2002 22:00 | R: 12.12.2002 21:00 | Winnaars: Málaga CF | ||||
| U | FC Porto | - | RC Lens | 3:0 (2:0) | ||
| R | RC Lens | - | FC Porto | 1:0 (1:0) | ||
| U: 28.11.2002 22:30 | R: 12.12.2002 21:15 | Winnaars: FC Porto | ||||
