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| U | RSC Anderlecht | - | Bayern München | 0:5 (0:2) | ||
| R | Bayern München | - | RSC Anderlecht | 1:2 (1:2) | ||
| U: 06.03.2008 19:00 | R: 12.03.2008 20:45 | Winnaars: Bayern München | ||||
| U | ACF Fiorentina | - | Everton FC | 2:0 (0:0) | ||
| R | Everton FC | - | ACF Fiorentina | 2:4 (1:0, 2:0, 2:0) d.p. | ||
| U: 06.03.2008 20:45 | R: 12.03.2008 20:45 | Winnaars: ACF Fiorentina | ||||
| U | Olympique Marseille | - | Zenit St. Petersburg | 3:1 (1:0) | ||
| R | Zenit St. Petersburg | - | Olympique Marseille | 2:0 (1:0) | ||
| U: 06.03.2008 20:45 | R: 12.03.2008 17:30 | Winnaars: Zenit St. Petersburg | ||||
| U | Rangers FC | - | Werder Bremen | 2:0 (1:0) | ||
| R | Werder Bremen | - | Rangers FC | 1:0 (0:0) | ||
| U: 06.03.2008 21:00 | R: 13.03.2008 20:30 | Winnaars: Rangers FC | ||||
| U | Bolton Wanderers | - | Sporting CP | 1:1 (1:0) | ||
| R | Sporting CP | - | Bolton Wanderers | 1:0 (0:0) | ||
| U: 06.03.2008 21:00 | R: 13.03.2008 21:00 | Winnaars: Sporting CP | ||||
| U | Bayer Leverkusen | - | Hamburger SV | 1:0 (0:0) | ||
| R | Hamburger SV | - | Bayer Leverkusen | 3:2 (0:1) | ||
| U: 06.03.2008 21:05 | R: 12.03.2008 17:45 | Winnaars: Bayer Leverkusen | ||||
| U | Tottenham Hotspur | - | PSV | 0:1 (0:1) | ||
| R | PSV | - | Tottenham Hotspur | 6:5 (0:0, 0:1, 0:1) d.p. | ||
| U: 06.03.2008 21:05 | R: 12.03.2008 20:45 | Winnaars: PSV | ||||
| U | SL Benfica | - | Getafe CF | 1:2 (0:1) | ||
| R | Getafe CF | - | SL Benfica | 1:0 (0:0) | ||
| U: 06.03.2008 21:30 | R: 12.03.2008 21:00 | Winnaars: Getafe CF | ||||
