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| U | Paris Saint-Germain | - | Chelsea FC | 2:1 (1:1) | ||
| R | Chelsea FC | - | Paris Saint-Germain | 1:2 (1:1) | ||
| U: 16.02.2016 20:45 | R: 09.03.2016 20:45 | Winnaars: Paris Saint-Germain | ||||
| U | SL Benfica | - | Zenit St. Petersburg | 1:0 (0:0) | ||
| R | Zenit St. Petersburg | - | SL Benfica | 1:2 (0:0) | ||
| U: 16.02.2016 20:45 | R: 09.03.2016 18:00 | Winnaars: SL Benfica | ||||
| U | KAA Gent | - | VfL Wolfsburg | 2:3 (0:1) | ||
| R | VfL Wolfsburg | - | KAA Gent | 1:0 (0:0) | ||
| U: 17.02.2016 20:45 | R: 08.03.2016 20:45 | Winnaars: VfL Wolfsburg | ||||
| U | AS Roma | - | Real Madrid | 0:2 (0:0) | ||
| R | Real Madrid | - | AS Roma | 2:0 (0:0) | ||
| U: 17.02.2016 20:45 | R: 08.03.2016 20:45 | Winnaars: Real Madrid | ||||
| U | Arsenal FC | - | FC Barcelona | 0:2 (0:0) | ||
| R | FC Barcelona | - | Arsenal FC | 3:1 (1:0) | ||
| U: 23.02.2016 20:45 | R: 16.03.2016 20:45 | Winnaars: FC Barcelona | ||||
| U | Juventus | - | Bayern München | 2:2 (0:1) | ||
| R | Bayern München | - | Juventus | 4:2 (0:2, 2:2) n.v. | ||
| U: 23.02.2016 20:45 | R: 16.03.2016 20:45 | Winnaars: Bayern München | ||||
| U | PSV | - | Atlético Madrid | 0:0 (0:0) | ||
| R | Atlético Madrid | - | PSV | 8:7 (0:0, 0:0, 0:0) d.p. | ||
| U: 24.02.2016 20:45 | R: 15.03.2016 20:45 | Winnaars: Atlético Madrid | ||||
| U | Dinamo Kiev | - | Manchester City | 1:3 (0:2) | ||
| R | Manchester City | - | Dinamo Kiev | 0:0 (0:0) | ||
| U: 24.02.2016 20:45 | R: 15.03.2016 20:45 | Winnaars: Manchester City | ||||
