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| U | Granada CF | - | Manchester United | 0:2 (0:1) | ||
| R | Manchester United | - | Granada CF | 2:0 (1:0) | ||
| U: 08.04.2021 21:00 | R: 15.04.2021 21:00 | Winnaars: Manchester United | ||||
| U | Arsenal FC | - | Slavia Praag | 1:1 (0:0) | ||
| R | Slavia Praag | - | Arsenal FC | 0:4 (0:3) | ||
| U: 08.04.2021 21:00 | R: 15.04.2021 21:00 | Winnaars: Arsenal FC | ||||
| U | AFC Ajax | - | AS Roma | 1:2 (1:0) | ||
| R | AS Roma | - | AFC Ajax | 1:1 (0:0) | ||
| U: 08.04.2021 21:00 | R: 15.04.2021 21:00 | Winnaars: AS Roma | ||||
| U | Dinamo Zagreb | - | Villarreal CF | 0:1 (0:1) | ||
| R | Villarreal CF | - | Dinamo Zagreb | 2:1 (2:0) | ||
| U: 08.04.2021 21:00 | R: 15.04.2021 21:00 | Winnaars: Villarreal CF | ||||
