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| U | Bayern München | - | Paris Saint-Germain | 1:2 (0:1) | ||
| R | Paris Saint-Germain | - | Bayern München | 2:2 (1:1, 1:2) n.v. | ||
| U: 22.03.2022 18:45 | R: 30.03.2022 21:00 | Winnaars: Paris Saint-Germain | ||||
| U | Real Madrid | - | FC Barcelona | 1:3 (1:0) | ||
| R | FC Barcelona | - | Real Madrid | 5:2 (1:1) | ||
| U: 22.03.2022 21:00 | R: 30.03.2022 18:45 | Winnaars: FC Barcelona | ||||
| U | Juventus | - | Olympique Lyon | 2:1 (0:1) | ||
| R | Olympique Lyon | - | Juventus | 3:1 (2:0) | ||
| U: 23.03.2022 18:45 | R: 31.03.2022 21:00 | Winnaars: Olympique Lyon | ||||
| U | Arsenal WFC | - | VfL Wolfsburg | 1:1 (0:1) | ||
| R | VfL Wolfsburg | - | Arsenal WFC | 2:0 (1:0) | ||
| U: 23.03.2022 21:00 | R: 31.03.2022 18:45 | Winnaars: VfL Wolfsburg | ||||
